Bone and Soft Tissue: Practice Question
Ring chromosome from 12q is most consistent with which of the following neoplasms?
- Pleomorphic liposarcoma
- Myxoid liposarcoma
- Hibernoma
- Lipoblastoma
- Well-differentiated liposarcoma
Show Answer and Explanations
Pleomorphic liposarcoma
Incorrect. Pleomorphic lioposarcomas tend to have complex karyotypes.Myxoid liposarcoma
Incorrect. Both myxoid and round cell liposarcomas are characterized by translocations of DDIT3 on chromosome 12.Hibernoma
Incorrect. These tumors are characterized by 11q23 rearrangements.Lipoblastoma
Incorrect. These tumors are characterized by 8q12 rearrangements.Well-differentiated liposarcoma — Correct answer
Correct. Well-differentiated and dedifferentiated liposarcoma are characterized by ring chromosomes of 12q, site of MDM2.Summary
Summary: For adipocytic tumors, cytogenetic characteristics are as follows:Well-differentiated and dedifferentiated liposarcoma: ring chromosome 12q
Myxoid/round cell liposarcoma: t(12;16) DDIT3-FUS or t(12;22) DDIT3-EWSR1
Hibernoma: 11q23 rearrangements
Lipoblastoma: 8q12 rearrangements
Chrondroid lipoma: t(11;16)
Pleomorphic liposarcoma: complex karyotype