Molecular & Ihc: Practice Question

Which of the following markers, if positive, would distinguish acute lymphoblastic leukemia from the leukemic variant of Burkitt lymphoma?
  1. Tdt
  2. CD19
  3. CD10
  4. S100
  5. Pax-5
Show Answer and Explanations

Tdt — Correct answer

Correct. Tdt is positive in lymphoblastic leukemia but not Burkitt lymphoma.

CD19

Incorrect. CD19 is positive in both acute lymphoblastic leukemia and the leukemic variant of Burkitt lymphoma.

CD10

Incorrect. CD10 is positive in both acute lymphoblastic leukemia and the leukemic variant of Burkitt lymphoma.

S100

Incorrect. S100 would not distinguish these.

Pax-5

Incorrect. Pax-5 is positive in both acute lymphoblastic leukemia and the leukemic variant of Burkitt lymphoma.

Summary

Summary: TdT positivity distinguishes B-lymphoblastic leukemia from the leukemic variant of Burkitt lymphoma.
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