What immunostain is positive in mucoepidermoid carcinoma and negative in mammary analogue secretory carcinoma?
S100
Androgen receptor
Her2/Neu
p63
Mammaglobin
Show Answer and Explanations
S100
Incorrect. S100 is positive in mammary analogue secretory carcinoma but negative in mucoepidermoid carcinoma.
Androgen receptor
Incorrect. AR is negative in both mucoepidermoid carcinoma and mammary analogue secretory carcinoma.
Her2/Neu
Incorrect. Her2/Neu is negative in both mucoepidermoid carcinoma and mammary analogue secretory carcinoma.
p63 — Correct answer
Correct. P63 is positive in mucoepidermoid carcinoma but not mammary analogue secretory carcinoma.
Mammaglobin
Incorrect. Mammaglobin is positive in mammary analogue secretory carcinoma but negative in mucoepidermoid carcinoma.
Summary
Summary: Mucoepidermoid carcinoma is positive for keratin, p63 and mucin (mucicarmine stain). Although mammary analogue secretory carcinoma also contains mucous cells, it is positive for S100 and mammaglobin and negative for p63.